Brain expressed microRNAs implicated in schizophrenia etiology.

ABSTRACT:

Background

Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with the identification of regulatory microRNAs (miRNAs) as important in brain development and function, miRNAs genes have emerged as candidates for schizophrenia-associated genetic factors. Indeed, the growing understanding of the regulatory properties and pleiotropic effects that miRNA have on molecular and cellular mechanisms, suggests that alterations in the interactions between miRNAs and their mRNA targets may contribute to phenotypic variation.

Methodology/principal findings

We have studied the association between schizophrenia and genetic variants of miRNA genes associated with brain-expression using a case-control study design on three Scandinavian sam

SUBMITTER: Hansen T 

PROVIDER: S-EPMC1964806 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature