A modular and extensible RNA-based gene-regulatory platform for engineering cellular function.

ABSTRACT: Engineered biological systems hold promise in addressing pressing human needs in chemical processing, energy production, materials construction, and maintenance and enhancement of human health and the environment. However, significant advancements in our ability to engineer biological systems have been limited by the foundational tools available for reporting on, responding to, and controlling intracellular components in living systems. Portable and scalable platforms are needed for the reliable construction of such communication and control systems across diverse organisms. We report an extensible RNA-based framework for engineering ligand-controlled gene-regulatory systems, called ribozyme switches, that exhibits tunable regulation, design modularity, and target specificity. These switch

SUBMITTER: Win MN 

PROVIDER: S-EPMC1964840 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature