Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.

ABSTRACT: Genome-wide association (GWA) studies offer a powerful unbiased method for the identification of multiple susceptibility genes for complex diseases. Here we report the results of a GWA study for Crohn's disease (CD) using family trios from the Quebec Founder Population (QFP). Haplotype-based association analyses identified multiple regions associated with the disease that met the criteria for genome-wide significance, with many containing a gene whose function appears relevant to CD. A proportion of these were replicated in two independent German Caucasian samples, including the established CD loci NOD2 and IBD5. The recently described IL23R locus was also identified and replicated. For this region, multiple individuals with all major haplotypes in the QFP were sequenced and extensive fine

SUBMITTER: Raelson JV 

PROVIDER: S-EPMC1965486 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature