HoxPred: automated classification of Hox proteins using combinations of generalised profiles.

ABSTRACT:

Background

Correct identification of individual Hox proteins is an essential basis for their study in diverse research fields. Common methods to classify Hox proteins focus on the homeodomain that characterise homeobox transcription factors. Classification is hampered by the high conservation of this short domain. Phylogenetic tree reconstruction is a widely used but time-consuming classification method.

Results

We have developed an automated procedure, HoxPred, that classifies Hox proteins in their groups of homology. The method relies on a discriminant analysis that classifies Hox proteins according to their scores for a combination of protein generalised profiles. 54 generalised profiles dedicated to each Hox homology group were produced de novo from a curated dataset of

SUBMITTER: Thomas-Chollier M 

PROVIDER: S-EPMC1965487 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature