Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists.

ABSTRACT: Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub-micromolar affinities at the mGluR5.

SUBMITTER: Kulkarni SS 

PROVIDER: S-EPMC1973162 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature