Caenorhabditis elegans neuronal regeneration is influenced by life stage, ephrin signaling, and synaptic branching.

ABSTRACT: We previously reported functional regeneration of Caenorhabditis elegans motor neurons after femtosecond laser axotomy. We report here that multiple neuronal types can regrow after laser axotomy using a variety of lasers. The precise pattern of regrowth varies with cell type, stage of animal, and position of axotomy. Mechanosensory axons cut in late larval or adult stages displayed extensive regrowth, yet failed to reach their target area because of guidance errors in the anteroposterior axis. By contrast, mechanosensory axons cut in early larval stages regrew at the same rate but with fewer anteroposterior guidance errors, and were more likely to reach their target area. In adult animals lacking the VAB-1 Eph receptor tyrosine kinase, mechanosensory axon regrowth was more accurate than in

SUBMITTER: Wu Z 

PROVIDER: S-EPMC1975853 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature