Linking metabolic QTLs with network and cis-eQTLs controlling biosynthetic pathways.

ABSTRACT: Phenotypic variation between individuals of a species is often under quantitative genetic control. Genomic analysis of gene expression polymorphisms between individuals is rapidly gaining popularity as a way to query the underlying mechanistic causes of variation between individuals. However, there is little direct evidence of a linkage between global gene expression polymorphisms and phenotypic consequences. In this report, we have mapped quantitative trait loci (QTLs)-controlling glucosinolate content in a population of 403 Arabidopsis Bay x Sha recombinant inbred lines, 211 of which were previously used to identify expression QTLs controlling the transcript levels of biosynthetic genes. In a comparative study, we have directly tested two plant biosynthetic pathways for association betwe

SUBMITTER: Wentzell AM 

PROVIDER: S-EPMC1976331 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature