Characterization of protein hubs by inferring interacting motifs from protein interactions.

ABSTRACT: The characterization of protein interactions is essential for understanding biological systems. While genome-scale methods are available for identifying interacting proteins, they do not pinpoint the interacting motifs (e.g., a domain, sequence segments, a binding site, or a set of residues). Here, we develop and apply a method for delineating the interacting motifs of hub proteins (i.e., highly connected proteins). The method relies on the observation that proteins with common interaction partners tend to interact with these partners through a common interacting motif. The sole input for the method are binary protein interactions; neither sequence nor structure information is needed. The approach is evaluated by comparing the inferred interacting motifs with domain families defined for 36

SUBMITTER: Aragues R 

PROVIDER: S-EPMC1976338 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature