CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease.

ABSTRACT: LPS from bacteria is ubiquitous in the environment and can cause airway disease and modify allergic asthma. Identification of gene products that modulate the biologic response to inhaled LPS will improve our understanding of inflammatory airways disease. Previous work has identified quantitative trait loci for the response to inhaled LPS on chromosomes 2 and 11. In these regions, 28 genes had altered RNA expression after inhalation of LPS, including CD44, which was associated with differences in both TNF-alpha levels and neutrophil recruitment into the lung. It has previously been shown that CD44 can modulate macrophage recruitment in response to Mycobacterium tuberculosis, as well as clearance of neutrophils after lung injury with both bleomycin and live Escherichia coli bacteria. In this

SUBMITTER: Hollingsworth JW 

PROVIDER: S-EPMC1976546 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature