Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032.

ABSTRACT:

Background

Bacillus spores are notoriously resistant to unfavorable conditions such as UV radiation, gamma-radiation, H2O2, desiccation, chemical disinfection, or starvation. Bacillus pumilus SAFR-032 survives standard decontamination procedures of the Jet Propulsion Lab spacecraft assembly facility, and both spores and vegetative cells of this strain exhibit elevated resistance to UV radiation and H2O2 compared to other Bacillus species.

Principal findings

The genome of B. pumilus SAFR-032 was sequenced and annotated. Lists of genes relevant to DNA repair and the oxidative stress response were generated and compared to B. subtilis and B. licheniformis. Differences in conservation of genes, gene order, and protein sequences are highlighted because they potentially explain th

SUBMITTER: Gioia J 

PROVIDER: S-EPMC1976550 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature