Inference of transcriptional regulation using gene expression data from the bovine and human genomes.

ABSTRACT:

Background

Gene expression is in part regulated by sequences in promoters that bind transcription factors. Thus, co-expressed genes may have shared sequence motifs representing putative transcription factor binding sites (TFBSs). However, for agriculturally important animals the genomic sequence is often incomplete. The more complete human genome may be able to be used for this prediction by taking advantage of the expected evolutionary conservation in TFBSs between the species.

Results

A method of de novo TFBS prediction based on MEME was implemented, tested, and validated on a muscle-specific dataset. Muscle specific expression data from EST library analysis from cattle was used to predict sets of genes whose expression was enriched in muscle and cardiac tissues. The upstr

SUBMITTER: Zadissa A 

PROVIDER: S-EPMC1978505 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature