Differential gene expression profile in the small intestines of mice lacking pacemaker interstitial cells of Cajal.

ABSTRACT:

Background

We previously identified eight known and novel genes differentially expressed in the small intestines of wild type and W/WV mice, which have greatly reduced populations of the interstitial cells of Cajal, that are responsible for the generation of electrical slow waves, by using a differential gene display method.

Methods

By using the same method we isolated additional candidate genes that were specifically down- or up-regulated in W/WV mice. Novel transcripts were designated as DDWMEST.

Results

We isolated seven candidates that were specifically down- or up-regulated in W/WV mice. Two novel transcripts, DDWMEST 1 and -91 were increased in both fed and fasted W/WV mice. Expression of another five genes was suppressed in W/WV mice: ARG2 (Arginase II), ONZIN

SUBMITTER: Daigo Y 

PROVIDER: S-EPMC198276 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature