Alternative splicing of the ADAR1 transcript in a region that functions either as a 5'-UTR or an ORF.

ABSTRACT: The ADAR enzymes mediate the hydrolytic deamination of adenosines in specific RNA substrates and thereby diversify both the transcriptome and the proteome in metazoan species. Three promoters drive the transcription from the ADAR1 gene yielding the ADAR1-A, -B, and -C transcripts, which, in turn, lead to the production of two protein isoforms, namely, iADAR1 and cADAR1. In this study, we establish the presence of a previously unidentified alternative intron within the 5'-end of the common second exon of mRNAs encoding ADAR1 in primate species-a region that can function either as a 5'-UTR or an ORF. In addition, it is shown that the relative expression of the three promoter-specific ADAR1 transcripts is tissue specific and that the novel intron is excised from all transcripts, but at differ

SUBMITTER: Lykke-Andersen S 

PROVIDER: S-EPMC1986812 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature