Transcriptome analysis of human immune responses following live vaccine strain (LVS) Francisella tularensis vaccination.

ABSTRACT: The live vaccine strain (LVS) of Francisella tularensis is the only vaccine against tularemia available for humans, yet its mechanism of protection remains unclear. We probed human immunological responses to LVS vaccination with transcriptome analysis using PBMC samples from volunteers at time points pre- and post-vaccination. Gene modulation was highly uniform across all time points, implying commonality of vaccine responses. Principal components analysis revealed three highly distinct principal groupings: pre-vaccination (-144 h), early (+18 and +48 h), and late post-vaccination (+192 and +336 h). The most significant changes in gene expression occurred at early post-vaccination time points (

SUBMITTER: Fuller CL 

PROVIDER: S-EPMC1986836 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature