Molecular portrait of cisplatin induced response in human testis cancer cell lines based on gene expression profiles.

ABSTRACT:

Background

Testicular germ cell tumors (TGCTs) respond well to cisplatin-based chemotherapy and show a low incidence of acquired resistance compared to most somatic tumors. The reasons for these specific characteristics are not known in detail but seem to be multifactorial. We have studied gene expression profiles of testicular and colon cancer derived cell lines treated with cisplatin. The main goal of this study was to identify novel gene expression profiles with their functional categories and the biochemical pathways that are associated with TGCT cells' response to cisplatin.

Results

Genes that were differentially expressed between the TGCT cell lines vs the (somatic) HCT116 cell line, after cisplatin treatment, were identified using the significance analysis of microarr

SUBMITTER: Duale N 

PROVIDER: S-EPMC1988831 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature