Cell-to-cell spread and massive vacuole formation after Cryptococcus neoformans infection of murine macrophages.

ABSTRACT:

Background

The interaction between macrophages and Cryptococcus neoformans (Cn) is critical for containing dissemination of this pathogenic yeast. However, Cn can either lyse macrophages or escape from within them through a process known as phagosomal extrusion. Both events result in live extracellular yeasts capable of reproducing and disseminating in the extracellular milieu. Another method of exiting the intracellular confines of cells is through host cell-to-cell transfer of the pathogen, and this commonly occurs with the human immuno-deficiency virus (HIV) and CD4+ T cells and macrophages. In this report we have used time-lapse imaging to determine if this occurs with Cn.

Results

Live imaging of Cryptococcus neoformans interactions with murine macrophages revealed cell-

SUBMITTER: Alvarez M 

PROVIDER: S-EPMC1988836 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature