Structure-templated predictions of novel protein interactions from sequence information.

ABSTRACT: The multitude of functions performed in the cell are largely controlled by a set of carefully orchestrated protein interactions often facilitated by specific binding of conserved domains in the interacting proteins. Interacting domains commonly exhibit distinct binding specificity to short and conserved recognition peptides called binding profiles. Although many conserved domains are known in nature, only a few have well-characterized binding profiles. Here, we describe a novel predictive method known as domain-motif interactions from structural topology (D-MIST) for elucidating the binding profiles of interacting domains. A set of domains and their corresponding binding profiles were derived from extant protein structures and protein interaction data and then used to predict novel protein

SUBMITTER: Betel D 

PROVIDER: S-EPMC1988853 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature