Negative autoregulation by FAS mediates robust fetal erythropoiesis.

ABSTRACT: Tissue development is regulated by signaling networks that control developmental rate and determine ultimate tissue mass. Here we present a novel computational algorithm used to identify regulatory feedback and feedforward interactions between progenitors in developing erythroid tissue. The algorithm makes use of dynamic measurements of red cell progenitors between embryonic days 12 and 15 in the mouse. It selects for intercellular interactions that reproduce the erythroid developmental process and endow it with robustness to external perturbations. This analysis predicts that negative autoregulatory interactions arise between early erythroblasts of similar maturation stage. By studying embryos mutant for the death receptor FAS, or for its ligand, FASL, and by measuring the rate of FAS-med

SUBMITTER: Socolovsky M 

PROVIDER: S-EPMC1988857 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature