Child-parent screening for familial hypercholesterolaemia: screening strategy based on a meta-analysis.

ABSTRACT:

Objective

To develop a population screening strategy for familial hypercholesterolaemia.

Design

Meta-analysis of published data on total and low density lipoprotein (LDL) cholesterol in people with and without familial hypercholesterolaemia according to age. Thirteen studies reporting on 1907 cases and 16 221 controls were used in the analysis. Included studies had at least 10 cases and controls with data on the distribution of cholesterol in affected and unaffected individuals.

Main outcome measures

Detection rates (sensitivity) for specified false positive rates (0.1%, 0.5%, and 1%) in newborns and in age groups 1-9, 10-19, 20-39, 40-59, and > or =60 years.

Results

Serum cholesterol concentration discriminated best between people with and without familial hyp

SUBMITTER: Wald DS 

PROVIDER: S-EPMC1989026 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature