Functional expression of "cardiac-type" Nav1.5 sodium channel in canine intracardiac ganglia.

ABSTRACT:

Background

The autonomic nervous system has been implicated in several arrhythmogenic diseases, including long QT syndrome type 3 (LQT3) and Brugada syndrome. Scarce information on the cellular components of the intrinsic cardiac ganglia from higher mammals has limited our understanding of the role of the autonomic nervous system in such diseases.

Objectives

The purpose of this study was to isolate and characterize the electrophysiologic properties of canine intracardiac neurons.

Methods

Action potentials (APs) and ionic currents were studied in enzymatically dissociated canine intracardiac neurons under current and voltage clamp conditions. Immunohistochemical and reverse transcription-polymerase chain reaction analysis was performed using freshly isolated intracardi

SUBMITTER: Scornik FS 

PROVIDER: S-EPMC1989775 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature