The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis.

ABSTRACT: Cell migration is fundamental in both animal morphogenesis and disease. The migration of individual cells is relatively well-studied; however, in vivo, cells often remain joined by cell-cell junctions and migrate in cohesive groups. How such groups of cells coordinate their migration is poorly understood. The planar polarity pathway coordinates the polarity of non-migrating cells in epithelial sheets and is required for cell rearrangements during vertebrate morphogenesis. It is therefore a good candidate to play a role in the collective migration of groups of cells. Drosophila border cell migration is a well-characterised and genetically tractable model of collective cell migration, during which a group of about six to ten epithelial cells detaches from the anterior end of the developing e

SUBMITTER: Bastock R 

PROVIDER: S-EPMC1991286 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature