Enhanced neurite growth from mammalian neurons in three-dimensional salmon fibrin gels.

ABSTRACT: Three-dimensional fibrin matrices have been used as cellular substrates in vitro and as bridging materials for central nervous system repair. Cells can be embedded within fibrin gels since the polymerization process is non-toxic, making fibrin an attractive scaffold for transplanted cells. Most studies have utilized fibrin prepared from human or bovine blood proteins. However, fish fibrin may be well suited for neuronal growth since fish undergo remarkable central nervous system regeneration and molecules implicated in this process are present in fibrin. We assessed the growth of mammalian central nervous system neurons in bovine, human, and salmon fibrin and found that salmon fibrin gels encouraged the greatest degree of neurite (dendrite and axon) growth and were the most resistant to de

SUBMITTER: Ju YE 

PROVIDER: S-EPMC1991290 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature