Carbon dioxide inhalation induces dose-dependent and age-related negative affectivity.

ABSTRACT:

Background

Carbon dioxide inhalation is known to induce an emotion similar to spontaneous panic in Panic Disorder patients. The affective response to carbon dioxide in healthy subjects was not clearly characterized yet.

Methodology/principal findings

Sixty-four healthy subjects underwent a double inhalation of four mixtures containing respectively 0, 9, 17.5 and 35% CO(2) in compressed air, following a double blind, cross-over, randomized design. Affective responses were assessed according to DSM IV criteria for panic, using an Electronic Visual Analogue Scale and the Panic Symptom List. It was demonstrated that carbon dioxide challenges induced a dose dependent negative affect (p<0.0001). This affect was semantically identical to the DSM IV definition of panic. Older indivi

SUBMITTER: Griez EJ 

PROVIDER: S-EPMC1991589 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature