A multidirectional non-cell autonomous control and a genetic interaction restricting tobacco etch virus susceptibility in Arabidopsis.

ABSTRACT:

Background

Viruses constitute a major class of pathogens that infect a variety of hosts. Understanding the intricacies of signaling during host-virus interactions should aid in designing disease prevention strategies and in understanding mechanistic aspects of host and pathogen signaling machinery.

Methodology/principal findings

An Arabidopsis mutant, B149, impaired in susceptibility to Tobacco etch virus (TEV), a positive strand RNA virus of picoRNA family, was identified using a high-throughput genetic screen and a counterselection scheme. The defects include initiation of infection foci, rate of cell-to-cell movement and long distance movement.

Conclusions/significance

The defect in infectivity is conferred by a recessive locus. Molecular genetic analysis and compl

SUBMITTER: Gopalan S 

PROVIDER: S-EPMC1991623 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature