Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats.

ABSTRACT:

Rationale

Inhaled nitric oxide (NO) has been used to prevent bronchopulmonary dysplasia, but with variable results. Ethyl nitrite (ENO) forms S-nitrosothiols more readily than does NO, and resists higher-order nitrogen oxide formation. Because S-nitrosylation is a key pathway mediating many NO biological effects, treatment with inhaled ENO may better protect postnatal lung development from oxidative stress than NO.

Objectives

To compare inhaled NO and ENO on hyperoxia-impaired postnatal lung development.

Methods

We treated newborn rats beginning at birth to air or 95% O(2) +/- 0.2-20.0 ppm ENO for 8 days, or to 10 ppm NO for 8 days. Pups treated with the optimum ENO dose, 10 ppm, and pups treated with 10 ppm NO were recovered in room air for 6 more days.

Measuremen

SUBMITTER: Auten RL 

PROVIDER: S-EPMC1994219 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature