Sex differences in severe pulmonary emphysema.

ABSTRACT:

Rationale

Limited data on sex differences in advanced COPD are available.

Objectives

To compare male and female emphysema patients with severe disease.

Methods

One thousand fifty-three patients (38.8% female) evaluated for lung volume reduction surgery as part of the National Emphysema Treatment Trial were analyzed.

Measurements and main results

Detailed clinical, physiological, and radiological assessment, including quantitation of emphysema severity and distribution from helical chest computed tomography, was completed. In a subgroup (n = 101), airway size and thickness was determined by histological analyses of resected tissue. Women were younger and exhibited a lower body mass index (BMI), shorter smoking history, less severe airflow obstruction, lower Dl(c

SUBMITTER: Martinez FJ 

PROVIDER: S-EPMC1994221 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature