Micro-Opioid receptor activation prevents acute hepatic inflammation and cell death.

ABSTRACT:

Background and aims

The detrimental impact of opioid agonist on the clinical management of inflammatory diseases remains elusive. Given the anti-inflammatory properties of the mu-opioid receptor (MOR) agonists at the intestinal barrier, we hypothesised that MOR activation might also dampen acute hepatic inflammation and cell death-major determinants in the pathogenesis of liver diseases.

Patients and methods

The expression of MOR in liver biopsy specimens and peripheral blood mononuclear cells of untreated patients with chronic hepatitis C virus infection and controls, primary hepatocytes and cell lines was determined by quantitative PCR, immunoblotting and/or immunohistochemistry. The effects of peripheral MOR agonist (d-Ala2,NMe-Phe4,Gly5-ol (DAMGO)) and/or antagonist (nal

SUBMITTER: Chakass D 

PROVIDER: S-EPMC1994379 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature