Differential distribution of inflammatory cells in large and small airways in smokers.

ABSTRACT:

Background

Smoking induces structural changes in the airways, and is considered a major factor in the development of airflow obstruction in chronic obstructive pulmonary disease. However, differences in inflammatory cell distribution between large airways (LA) and small airways (SA) have not been systematically explored in smokers.

Hypothesis

The content of cells infiltrating the airway wall differs between LA and SA.

Aims

To compare the content of neutrophils, macrophages, lymphocytes and mast cells infiltrating LA and SA in smokers who underwent surgery for lung cancer.

Methods

Lung tissue from 15 smokers was analysed. Inflammatory cells in the lamina propria were identified by immunohistochemical analysis, quantified by digital image analysis and expressed a

SUBMITTER: Battaglia S 

PROVIDER: S-EPMC1994511 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature