Delta and Egfr expression are regulated by Importin-7/Moleskin in Drosophila wing development.

ABSTRACT: Drosophila DIM-7 (encoded by the moleskin gene, msk) is the orthologue of vertebrate Importin-7. Both Importin-7 and Msk/DIM-7 function as nuclear import cofactors, and have been implicated in the control of multiple signal transduction pathways, including the direct nuclear import of the activated (phosphorylated) form of MAP kinase. We performed two genetic deficiency screens to identify deficiencies that similarly modified Msk overexpression phenotypes in both eyes and wings. We identified 11 total deficiencies, one of which removes the Delta locus. In this report, we show that Delta loss-of-function alleles dominantly suppress Msk gain-of-function phenotypes in the developing wing. We find that Msk overexpression increases both Delta protein expression and Delta transcription, though M

SUBMITTER: Vrailas-Mortimer AD 

PROVIDER: S-EPMC1994573 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature