Adaptive evolution of a stress response protein.

ABSTRACT:

Background

Some cancers are mediated by an interplay between tissue damage, pathogens and localised innate immune responses, but the mechanisms that underlie these linkages are only beginning to be unravelled.

Methods and principal findings

Here we identify a strong signature of adaptive evolution on the DNA sequence of the mammalian stress response gene SEP53, a member of the epidermal differentiation complex fused-gene family known for its role in suppressing cancers. The SEP53 gene appears to have been subject to adaptive evolution of a type that is commonly (though not exclusively) associated with coevolutionary arms races. A similar pattern of molecular evolution was not evident in the p53 cancer-suppressing gene.

Conclusions

Our data thus raises the possibility

SUBMITTER: Little TJ 

PROVIDER: S-EPMC1994589 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature