Greater incidence of depression with hypnotic use than with placebo.

ABSTRACT:

Background

Although it has been claimed that insomnia causes an increased risk for depression, adequate controlled trials testing this hypothesis have not been available. This study contrasted the incidence of depression among subjects receiving hypnotics in randomized controlled trials versus those receiving placebo.

Methods

The incidence of depression among patients randomized to hypnotic drugs or placebo was compiled from prescribing information approved by the United States Food and Drug Administration (FDA) and from FDA New Drug Application documents. Available data for zolpidem, zaleplon, eszopiclone, and ramelteon were accessed.

Results

Data for 5535 patients randomized to a hypnotic and for 2318 randomized to placebo were compiled. The incidence of depression

SUBMITTER: Kripke DF 

PROVIDER: S-EPMC1994947 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature