The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study.

ABSTRACT:

Unlabelled

Evidence suggests that interleukin-1 receptor-associated kinase-1 (IRAK1), fundamental in the toll-like receptor pathway (TLR), may play a more specific role in atherosclerosis.

Methods

Caucasian women (N=529) and men (N=467) from the Diabetes Heart Study (DHS) were genotyped at four loci within the IRAK1 gene located on the X chromosome. Generalized estimating equations (GEE1) were used to evaluate association with C-reactive protein (CRP) for both single SNP and haplotype analyses.

Results

For each SNP genotyped, Caucasian women carrying one or two copies of the variant allele had greater CRP concentrations than those carrying the common genotype in both crude and adjusted models. There were 2 major haplotypes, CTTT (82%) and its complement TCCG (13%). Th

SUBMITTER: Lakoski SG 

PROVIDER: S-EPMC1995105 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature