Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial.

ABSTRACT:

Background

Physical function and exercise capacity decline with age and are a major source of disability in older people. Recent evidence suggests a potential role for the renin-angiotensin system in modulating muscle function. We sought to examine the effect of the angiotensin-converting-enzyme (ACE) inhibitor perindopril on physical function in elderly people with functional impairment who had no heart failure or left ventricular systolic dysfunction.

Methods

In this double-blind randomized controlled trial, participants aged 65 years and older who had problems with mobility or functional impairment were randomly assigned to receive either perindopril or placebo for 20 weeks. The primary outcome was the change in the 6-minute walking distance over the 20 weeks. Secondary o

SUBMITTER: Sumukadas D 

PROVIDER: S-EPMC1995143 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature