Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH): study protocol.

ABSTRACT:

Background

Young women presenting with breast cancer are more likely to have a genetic predisposition to the disease than breast cancer patients in general. A genetic predisposition is known to increase the risk of new primary breast (and other) cancers. It is unclear from the literature whether genetic status should be taken into consideration when planning adjuvant treatment in a young woman presenting with a first primary breast cancer. The primary aim of the POSH study is to establish whether genetic status influences the prognosis of primary breast cancer independently of known prognostic factors.

Methods/design

The study is a prospective cohort study recruiting 3,000 women aged 40 years or younger at breast cancer diagnosis; the recruiting period covers 1st June 2001 t

SUBMITTER: Eccles D 

PROVIDER: S-EPMC1995215 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature