Characterization of novel transforming growth factor-beta type I receptors found in malignant pleural effusion tumor cells.

ABSTRACT:

Background

Tumors expressing a transforming growth factor-beta type I receptor (T beta RI) mutant with sequence deletions in a nine-alanine (9A) stretch of the signal peptide are reported to be highly associated with disease progression. Expression of this mutant could interfere with endogenous TGFbeta signaling in the cell. However, little is known about the importance of the remaining part of the signal peptide on the cellular function of T beta RI.

Results

We cloned and identified four new in-frame deletion variants of T beta RI, designated DM1 to DM4, in pleural effusion-derived tumor cells. Intriguingly, DM1 and DM2, with a small region truncated in the putative signal peptide of T beta RI, had a serious defect in their protein expression compared with that of the wild-

SUBMITTER: Chen KL 

PROVIDER: S-EPMC1995218 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature