Influence of degree correlations on network structure and stability in protein-protein interaction networks.

ABSTRACT:

Background

The existence of negative correlations between degrees of interacting proteins is being discussed since such negative degree correlations were found for the large-scale yeast protein-protein interaction (PPI) network of Ito et al. More recent studies observed no such negative correlations for high-confidence interaction sets. In this article, we analyzed a range of experimentally derived interaction networks to understand the role and prevalence of degree correlations in PPI networks. We investigated how degree correlations influence the structure of networks and their tolerance against perturbations such as the targeted deletion of hubs.

Results

For each PPI network, we simulated uncorrelated, positively and negatively correlated reference networks. Here, a simpl

SUBMITTER: Friedel CC 

PROVIDER: S-EPMC1995226 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature