The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports.

ABSTRACT:

Background

The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. Many collected phenotypes have substantial genetic contributors; yet most genetic determinants remain to be identified. Using single nucleotide polymorphisms (SNPs) from a 100K genome-wide scan, we examine the associations of common polymorphisms with phenotypic variation in this community-based cohort and provide a full-disclosure, web-based resource of results for future replication studies.

Methods

Adult participants (n = 1345) of the largest 310 pedigrees in the FHS, many biologically related, were genotyped with the 100K Affymetrix GeneChip. These genotypes were used t

SUBMITTER: Cupples LA 

PROVIDER: S-EPMC1995613 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature