Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.

ABSTRACT:

Background

Increased circulating levels of hemostatic factors as well as anemia have been associated with increased risk of cardiovascular disease (CVD). Known associations between hemostatic factors and sequence variants at genes encoding these factors explain only a small proportion of total phenotypic variation. We sought to confirm known putative loci and identify novel loci that may influence either trait in genome-wide association and linkage analyses using the Affymetrix GeneChip 100K single nucleotide polymorphism (SNP) set.

Methods

Plasma levels of circulating hemostatic factors (fibrinogen, factor VII, plasminogen activator inhibitor-1, von Willebrand factor, tissue plasminogen activator, D-dimer) and hematological phenotypes (platelet aggregation, viscosity, hemog

SUBMITTER: Yang Q 

PROVIDER: S-EPMC1995619 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature