Comparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease.

ABSTRACT: One of the long-term goals of mutagenesis programs in the mouse has been to generate mutant lines to facilitate the functional study of every mammalian gene. With a combination of complementary genetic approaches and advances in technology, this aim is slowly becoming a reality. One of the most important features of this strategy is the ability to identify and compare a number of mutations in the same gene, an allelic series. With the advent of gene-driven screening of mutant archives, the search for a specific series of interest is now a practical option. This review focuses on the analysis of multiple mutations from chemical mutagenesis projects in a wide variety of genes and the valuable functional information that has been obtained from these studies. Although gene knockouts and transg

SUBMITTER: Oliver PL 

PROVIDER: S-EPMC1998876 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature