Microtubule-based nuclear movement occurs independently of centrosome positioning in migrating neurons.

ABSTRACT: During neuronal migration in the developing brain, it is thought that the centrosome precedes the nucleus and provides a cue for nuclear migration along the microtubules. In time-lapse imaging studies of radially migrating granule cells in mouse cerebellar slices, we observed that the movements of the nucleus and centrosome appeared to occur independently of each other. The nucleus often migrated ahead of the centrosome during its saltatory movement, negating the supposed role of the centrosome in pulling the nucleus. The nucleus was associated with dynamic microtubules enveloping the entire nucleus and stable microtubules extending from the leading process to the anterior part of the nucleus. Neither of these perinuclear microtubules converged at the centrosome. Disruption or excess forma

SUBMITTER: Umeshima H 

PROVIDER: S-EPMC2000450 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature