Protein kinase C delta is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes.

ABSTRACT: Activation of macrophages and subsequent "killing" effector functions against infectious pathogens are essential for the establishment of protective immunity. NF-IL6 is a transcription factor downstream of IFN-gamma and TNF in the macrophage activation pathway required for bacterial killing. Comparison of microarray expression profiles of Listeria monocytogenes (LM)-infected macrophages from WT and NF-IL6-deficient mice enabled us to identify candidate genes downstream of NF-IL6 involved in the unknown pathways of LM killing independent of reactive oxygen intermediates and reactive nitrogen intermediates. One differentially expressed gene, PKCdelta, had higher mRNA levels in the LM-infected NF-IL6-deficient macrophages as compared with WT. To define the role of PKCdelta during listeriosis,

SUBMITTER: Schwegmann A 

PROVIDER: S-EPMC2000452 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature