Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance.

ABSTRACT: Long-term allograft survival generally requires lifelong immunosuppression (IS). Rarely, recipients display spontaneous "operational tolerance" with stable graft function in the absence of IS. The lack of biological markers of this phenomenon precludes identification of potentially tolerant patients in which IS could be tapered and hinders the development of new tolerance-inducing strategies. The objective of this study was to identify minimally invasive blood biomarkers for operational tolerance and use these biomarkers to determine the frequency of this state in immunosuppressed patients with stable graft function. Blood gene expression profiles from 75 renal-transplant patient cohorts (operational tolerance/acute and chronic rejection/stable graft function on IS) and 16 healthy individu

SUBMITTER: Brouard S 

PROVIDER: S-EPMC2000539 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature