Production of Recombinant Peanut Allergen Ara h 2 using Lactococcus lactis.

ABSTRACT:

Background

Natural allergen sources can supply large quantities of authentic allergen mixtures for use as immunotherapeutics. However, such extracts are complex, difficult to define, vary from batch to batch, which may lead to unpredictable efficacy and/or unacceptable levels of side effects. The use of recombinant expression systems for allergen production can alleviate some of these issues. Several allergens have been tested in high-level expression systems and in most cases show immunereactivity comparable to their natural counterparts. The gram positive lactic acid bacterium Lactococcus lactis is an attractive microorganism for use in the production of protein therapeutics. L. lactis is considered food grade, free of endotoxins, and is able to secrete the heterologous product t

SUBMITTER: Glenting J 

PROVIDER: S-EPMC2000909 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature