Reduced expression of autotaxin predicts survival in uveal melanoma.

ABSTRACT:

Aim

In an effort to identify patients with uveal melanoma at high risk of metastasis, the authors undertook correlation of gene expression profiles with histopathology data and tumour-related mortality.

Methods

The RNA was isolated from 27 samples of uveal melanoma from patients who had consented to undergo enucleation, and transcripts profiled using a cDNA array comprised of sequence-verified cDNA clones representing approximately 4000 genes implicated in cancer development. Two multivariate data mining techniques--hierarchical cluster analysis and multidimensional scaling--were used to investigate the grouping structure in the gene expression data. Cluster analysis was performed with a subset of 10,000 randomly selected genes and the cumulative contribution of all the gene

SUBMITTER: Singh AD 

PROVIDER: S-EPMC2001033 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature