Severe respiratory syncytial virus bronchiolitis in infants is associated with reduced airway interferon gamma and substance P.

ABSTRACT:

Background

Severe human respiratory syncytial virus (hRSV) bronchiolitis in previously well infants may be due to differences in the innate immune response to hRSV infection.

Aim

to determine if factors mediating proposed mechanisms for severe bronchiolitis differ with severity of disease.

Methodology/principle findings

197 infants admitted to hospital with hRSV bronchiolitis were recruited and grouped according to no oxygen requirement (n = 27), oxygen dependence (n = 114) or mechanical ventilation (n = 56). We collected clinical data, nasopharyngeal aspirate (NPA) and if ventilated bronchoalveolar lavage (BAL). Interferon-gamma (IFN-gamma), substance P (SP), interleukin 9 (IL-9), urea and hRSV load, were measured in cell free supernatant from NPA and BAL. Multivaria

SUBMITTER: Semple MG 

PROVIDER: S-EPMC2001182 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature