Assembly of inflammation-related genes for pathway-focused genetic analysis.

ABSTRACT: Recent identifications of associations between novel variants in inflammation-related genes and several common diseases emphasize the need for systematic evaluations of these genes in disease susceptibility. Considering that many genes are involved in the complex inflammation responses and many genetic variants in these genes have the potential to alter the functions and expression of these genes, we assembled a list of key inflammation-related genes to facilitate the identification of genetic associations of diseases with an inflammation-related etiology. We first reviewed various phases of inflammation responses, including the development of immune cells, sensing of danger, influx of cells to sites of insult, activation and functional responses of immune and non-immune cells, and resolut

SUBMITTER: Loza MJ 

PROVIDER: S-EPMC2001184 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature