Gene expression signature in peripheral blood detects thoracic aortic aneurysm.

ABSTRACT:

Background

Thoracic aortic aneurysm (TAA) is usually asymptomatic and associated with high mortality. Adverse clinical outcome of TAA is preventable by elective surgical repair; however, identifying at-risk individuals is difficult. We hypothesized that gene expression patterns in peripheral blood cells may correlate with TAA disease status. Our goal was to identify a distinct gene expression signature in peripheral blood that may identify individuals at risk for TAA.

Methods and findings

Whole genome gene expression profiles from 94 peripheral blood samples (collected from 58 individuals with TAA and 36 controls) were analyzed. Significance Analysis of Microarray (SAM) identified potential signature genes characterizing TAA vs. normal, ascending vs. descending TAA, and spor

SUBMITTER: Wang Y 

PROVIDER: S-EPMC2002514 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature