Iron superoxide dismutases targeted to the glycosomes of Leishmania chagasi are important for survival.

ABSTRACT: Kinetoplastid glycosomes contain a variety of metabolic activities, such as glycolysis, beta-oxidation of fatty acids, lipid biosynthesis, and purine salvage. One advantage of sequestering metabolic activities is the avoidance of cellular oxidative damage by reactive oxygen species produced as a by-product of metabolism. Little is known about how glycosomes themselves withstand these toxic metabolites. We previously isolated an iron superoxide dismutase from Leishmania chagasi that is expressed at low levels in the early logarithmic promastigote stage and increases toward the stationary promastigote and amastigote stages. We have since identified a second highly homologous Lcfesodb gene that is expressed at high levels in the early logarithmic promastigote stage and decreases toward the st

SUBMITTER: Plewes KA 

PROVIDER: S-EPMC201062 | biostudies-literature | 2003 Oct

REPOSITORIES: biostudies-literature