Horizontal gene transfer regulation in bacteria as a "spandrel" of DNA repair mechanisms.

ABSTRACT: Horizontal gene transfer (HGT) is recognized as the major force for bacterial genome evolution. Yet, numerous questions remain about the transferred genes, their function, quantity and frequency. The extent to which genetic transformation by exogenous DNA has occurred over evolutionary time was initially addressed by an in silico approach using the complete genome sequence of the Ralstonia solanacearum GMI1000 strain. Methods based on phylogenetic reconstruction of prokaryote homologous genes families detected 151 genes (13.3%) of foreign origin in the R. solanacearum genome and tentatively identified their bacterial origin. These putative transfers were analyzed in comparison to experimental transformation tests involving 18 different genomic DNA positions in the genome as sites for homol

SUBMITTER: Fall S 

PROVIDER: S-EPMC2013936 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature