Pro-inflammatory effects of early non-enzymatic glycated proteins in human mesothelial cells vary with cell donor's age.

ABSTRACT:

Background and purpose

Diabetes mellitus is prevalent in the elderly population. It is also a disease causing tissue damage through several different mechanisms. Some of these mechanisms are also activated by ageing and this overlap raises questions about how diabetes induces damage in the elderly. Early products of non-enzymatic glycation of proteins (Amadori adducts), and the ageing process share the capacity to induce oxidative stress and inflammation in human peritoneal mesothelial cells (HPMCs). We have evaluated the interactions between the age of the donor of the HPMCs and the pro-inflammatory effects of Amadori adducts in those cells.

Experimental approach

HPMCs were isolated from 20 individuals (age range 21-81 years) and grown in culture. Using different experiment

SUBMITTER: Rodriguez-Manas L 

PROVIDER: S-EPMC2014639 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature